Bei Roche kannst du ganz du selbst sein und wirst für deine einzigartigen Qualitäten geschätzt. Unsere Kultur fördert persönlichen Ausdruck, offenen Dialog und echte Verbindungen. Hier wirst du für das, was du bist, wertgeschätzt, akzeptiert und respektiert. Dies schafft ein Umfeld, in dem du sowohl persönlich als auch beruflich wachsen kannst. Gemeinsam wollen wir Krankheiten vorbeugen, stoppen und heilen und sicherstellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und in Zukunft. Werde Teil von Roche, wo jede Stimme zählt.
Die Position
In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary, life-changing innovation at speed.
At the intersection of science and innovation, pRED’s Pharmaceutical Sciences (PS) organisation enables the discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines. By seamlessly integrating our three core pillars—Translational Safety, Translational Pharmacology, and Biomarkers - we drive end-to-end asset development across the entire value chain, from target assessment to on-market support. Our mission is to continuously improve predictive accuracy, optimise dosing strategies for the right patient populations, and accelerate the development of tomorrow's safe and effective therapeutics.
This position is located in Pathology and Applied Safety Science, a department within the Pharmaceutical Sciences function. We drive the non-clinical safety assessment of drug candidates from small molecules to complex biological products during the discovery and development phases at Roche.
The Opportunity
- In Vivo - in vitro Immunosafety Integration& Mechanistic Strategy: Formulate, implement, and champion integrated immunosafety strategies for portfolio projects, ensuring the scientific validation and execution of predictive immunological biomarkers. Interrogate and decode in vivo immunosafety findings (e.g., changes in lymphoid architecture, immunogenicity readouts, cytokine profiles, or systemic hypersensitivities) and connect them back to mechanistic context using investigative in vitro tools. Translate complex immunological findings into unified safety position documentation, presenting definitive impact summaries for target validation, compound profiling, and IND/CTA-enabling packages.
- Advancing In Vitro Cellular Models via Immunological Elements: Proactively apply human immunology elements (e.g., primary immune cells, immune-epithelial co-cultures, inflammatory stimulus circuits) to upgrade the physiological accuracy of predictive in vitro cell models. Pioneer the optimisation, validation, and scale of 2D, 3D, and fluidic microphysiological safety systems, ensuring that models capture intricate human-specific responses like cytokine release syndromes, immune-mediated organ toxicities, or structural hypersensitivities. Drive proficiency in state-of-the-art analytical platforms such as high-content screening, flow cytometry, multiplexed fluid assays, and spatial or transcriptomic single-cell readouts.
- Proactive Data Curation, Reporting,& LIMS Operations: Conduct rigorous data analysis, critical validation of assays, and proper internal reporting of study phase data within the Laboratory Information Management System (LIMS). Act as the lead presenter of immunotoxicology assessments, translating highly specialised immune data into actionable, easy-to-digest go/no-go recommendations for project toxicologists and multi-disciplinary teams. Ensure impeccable documentation, maintain pristine raw data storage folders, and strictly fulfil international compliance archiving requirements.
- Quality, Compliance, and Laboratory Standards: Oversee and evaluate study data compliance under existing work instructions, Standard Operating Procedures (SOPs), and strict safety regulations, logging experimental deviations comprehensively. Comply with Safety, Health, and Environmental (SHE) regulations, championing mindful handling, storage, and ethical processing of materials from animal or human origins.
- Multi-Disciplinary Collaboration& Initiative: Serve as a collaborative scientific anchor across pathobiology, wet-lab toxicologists, and clinical safety to break down functional silos and rapidly resolve complex safety anomalies. Act with foresight and urgency to proactively design and execute targeted investigative protocols that address emerging portfolio liabilities before they impact project milestones. Consistently engage with internal peers, chapter lines, and stakeholders to efficiently prioritise and align laboratory resource flows under demanding schedules.
- Continuous Process Optimisation& Vendor Engagement: Drive an agile laboratory mindset focused on process optimisation to permanently elevate assay reproducibility, automate computational imaging inputs, and shorten compound turnaround times. Establish and sustain strategic relationships with external technology providers, Contract Research Organisations (CROs), and international scientific bodies to continuously benchmark and onboard next-generation immunotoxicology concepts.
Who you are
- You hold a PhD degree in an immunology-related field, with a strong industry focus on in vitro and/or in vivo human immunology or immunotoxicology assessment.
- You bring demonstrated experience formulating integrated immunosafety strategies and upgrading predictive cell models (including 2D, 3D, and fluidic microphysiological systems) using state-of-the-art analytical platforms like flow cytometry and high-content screening.
- You possess strong proficiency in data curation, critical assay validation, and LIMS reporting, with a proven ability to translate complex data into unified safety position documentation, actionable go/no-go recommendations, and IND/CTA-enabling packages.
- You demonstrate exceptional interpersonal skills and matrix flexibility, acting as a trusted scientific anchor who connects global teams, optimises laboratory processes for efficiency, and embraces entrepreneurial thinking under the Roche Leadership Framework (Creative Mindset, VACC).
At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you.
Wer wir sind
Eine gesündere Zukunft treibt uns zur Innovation an. Mehr als 100.000 Mitarbeiter weltweit arbeiten gemeinsam daran, wissenschaftliche Fortschritte zu erzielen und sicherzustellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und für zukünftige Generationen. Durch unser Engagement werden über 26 Millionen Menschen mit unseren Medikamenten behandelt und mehr als 30 Milliarden Tests mit unseren Diagnostik-Produkten durchgeführt. Wir ermutigen uns gegenseitig, neue Möglichkeiten zu erkunden, Kreativität zu fördern und hohe Ziele zu setzen, um lebensverändernde Gesundheitslösungen zu liefern.
Gemeinsam können wir eine gesündere Zukunft gestalten.
Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.
