The Schwank Lab at the University of Zurich develops and translates next-generation genome-engineering technologies toward therapeutic applications. Our interdisciplinary research combines CRISPR-based genome editing, advanced delivery technologies, disease models, and preclinical studies, with major programmes in metabolic liver diseases, neurological disorders, and immune-cell engineering. A particular focus is the development of genome-editing therapies for urea cycle disorders, and we are currently advancing selected programmes toward clinical translation.

Your responsibilities

Plan, coordinate and conduct in vivo studies in mouse models of genetic liver disease required for the initiation of clinical trials.
Administer genome-editing therapeutics and other test substances using relevant routes of delivery.
Perform animal monitoring, blood and tissue collection, necropsies, organ harvesting and downstream sample processing.
Perform molecular and cellular biology experiments, including mammalian cell culture, DNA and RNA isolation, PCR/qPCR, cloning and preparation of samples for sequencing.
Analyse, interpret and document experimental results and contribute to the optimisation of experimental protocols.
Maintain accurate records and ensure that all animal experiments are conducted in accordance with approved protocols and Swiss animal-welfare regulations.
Collaborate closely with scientists, students and external project partners across several parallel research projects.

Your profile

BSc or MSc in molecular biology, biotechnology, biomedicine, veterinary medicine, pharmaceutical sciences or a related discipline.
Substantial hands-on experience conducting experiments with mice is essential.
Candidates should be confident in animal handling and in relevant experimental procedures such as dosing/injections, monitoring, blood sampling, tissue collection and necropsy.
Strong practical experience in molecular and cellular biology (cloning, cell culture) and careful handling of biological samples.
Experience with CRISPR genome editing, RNA therapeutics, lipid nanoparticles, viral vectors, liver biology or metabolic disease models is an advantage but not required.
Ability to organise and conduct experiments independently, troubleshoot procedures and contribute effectively to multiple projects.
A highly reliable, precise and collaborative working style, with strong attention to animal welfare and experimental documentation.
Good written and spoken English.

Information on your application

Please submit your application as a single PDF containing a motivation letter, curriculum vitae, relevant certificates (including laboratory-animal training, where applicable) and contact details for two referees.

What we offer

Work-Life Balance

Flexible working models (such as part-time positions, mobile working, job-sharing)
Childcare at the kihz foundation of UZH and ETH

Learning and Development

Wide range of continuing education courses of UZH and the Canton of Zurich
Language Center run jointly with ETH Zurich

Food

Food and drinks at reduced prices in the UZH cafeterias
Lunch-Check-card with UZH contribution

Healthcare

Special conditions on the Academic Sports Association ASVZ
Free seasonal flu vaccinations
Rest and relaxation at the quiet room in the university tower

Discounts

Private traffic: Carsharing, rent a vehicle, parking space
Digitalization: Hardware, software, mobile phone subscriptions

Conditions of Employment

Policies of the UZH
Most UZH staff are employed according to public law

International Services

Support for people from outside Switzerland

Campuses

Campuses Zurich City, Zurich Irchel, Oerlikon and Schlieren
Sites Zurich West, Old Botanical Garden, Botanical Garden and Lengg

Location

Schwank Lab, Institute of Pharmacology, University of Zurich

Winterthurerstrasse 190, 8057 Zürich, Switzerland

Further information

Questions about the job

Gerald Schwank Professor, Group Leader

Working at UZH

The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!

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Your responsibilities

Your profile

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Location

Schwank Lab, Institute of Pharmacology, University of Zurich

Further information

Questions about the job

Working at UZH

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