The Laboratory for Molecular Neuro-Oncology at the University of Zurich is seeking a highly motivated postdoctoral researcher to join an ERC-funded project developing next-generation chimeric antigen receptor (CAR) immune cell therapies against malignant brain tumors.

What we Offer:

A fully funded postdoctoral position within a prestigious ERC-funded project
Access to cutting-edge engineering, screening, and profiling platforms
An interdisciplinary and collaborative environment at the forefront of cancer, immunology, and neuroscience
Opportunities to engage with translational and clinical research
Mentorship from leaders in the field and full support for a successful career in academia or in the entrepreneurial space

Background:
Malignant primary brain tumors remain among the most challenging tumor types to treat. Cancer immunotherapies hold revolutionary potential, and our group has pioneered multiple immunotherapeutic approaches against brain cancer, including tumor-targeted cytokine therapies (Weiss et al., Science Translational Medicine 2020; Look et al., Science Translational Medicine 2023) and engineered immune cell therapies (Sun et al., Science Translational Medicine 2025), leveraging sophisticated in vitro and in vivo models and cutting-edge technologies. Our team also has a strong track record of translating preclinical innovation into patient care.

Project Description:
In this ERC-funded project, the successful candidate will develop the next generation of immune cell therapies. Building on our established ex vivo and in vivo engineering platforms, sophisticated single-cell and spatial technologies, disease models, and patient samples, the project aims to further develop multifunctional, multi-immune-cell strategies for the treatment of malignant brain tumors.

Your responsibilities

Specific project goals:

Generate CAR immune cell communities, comprising mixtures of engineered T cells, NK cells, monocytes, and additional cell types, using sophisticated in vitro and in vivo engineering platforms.
Identify co-factors that boost CAR immune cell function using cutting-edge screening platforms.
Investigate anti-tumor activity and immune-cancer-cell environmental crosstalk in vitro and in vivo using sophisticated disease models (organoids, slice cultures, patient-derived samples, mouse models) and modern technologies including flow cytometry, multiplexed imaging, spatial transcriptomics/proteomics and single-cell profiling.
Analyze patient samples from an accompanying clinical trial evaluating CAR immune cell communities.

Your profile

Intellectual curiosity, creativity and a proactive approach to problem-solving
Motivation to contribute to a project with direct patient impact
PhD in immunology, computational immunology, cell/molecular/cancer biology, bioengineering, biomedical sciences, or a related field
Experience with immune cell engineering, cellular immunotherapy, and/or advanced in vitro/in vivo disease models is highly desirable
Familiarity with single-cell and/or spatial technologies is a plus
Strong publication record demonstrating scientific productivity
Excellent communication skills and the ability to thrive in an interdisciplinary team

Information on your application

Please send a single PDF containing the following documents:

Cover letter (max. 1 page) outlining your motivation, relevant experience
Detailed CV
Publication list
A brief research statement about the future research that you envision
Contact details of 2–3 professional references

What we offer

Work-Life Balance

Flexible working models (such as part-time positions, mobile working, job-sharing)
Childcare at the kihz foundation of UZH and ETH

Learning and Development

Wide range of continuing education courses of UZH and the Canton of Zurich
Language Center run jointly with ETH Zurich

Food

Food and drinks at reduced prices in the UZH cafeterias
Lunch-Check-card with UZH contribution

Healthcare

Special conditions on the Academic Sports Association ASVZ
Free seasonal flu vaccinations
Rest and relaxation at the quiet room in the university tower

Discounts

Private traffic: Carsharing, rent a vehicle, parking space
Digitalization: Hardware, software, mobile phone subscriptions

Conditions of Employment

Policies of the UZH
Most UZH staff are employed according to public law

International Services

Support for people from outside Switzerland

Campuses

Campuses Zurich City, Zurich Irchel, Oerlikon and Schlieren
Sites Zurich West, Old Botanical Garden, Botanical Garden and Lengg

Location

Department for Neurology

Frauenklinikstrasse 26, 8006 Zürich, Switzerland

Further information

Questions about the job

Tobias Weiss Prof. Dr. med. Dr. sc. nat.

Questions about the application procedure

Tobias Weiss Prof. Dr. med. Dr. sc. nat.

Working at UZH

The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!

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